Valproate in the treatment of PTSD: systematic review and meta analysis

Adamou, Marios and Puchalska, Sylvia and Plummer, William and Hale, Anthony S. (2007) Valproate in the treatment of PTSD: systematic review and meta analysis. Current Medical Research and Opinion, 23 (6). pp. 1285-1291. ISSN 0300-7995. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Objective: Anticonvulsants are used in clinical practice for the treatment of PTSD. However, a systematic investigation of their effects in the treatment of PTSD is currently lacking from the literature. Our aim is to review and appraise the evidence for the use of the anticonvulsant valproate for the treatment of PTSD. Methods: We performed a systematic review and meta-analysis of the literature where valproate was used for the treatment of PTSD. Studies of treatment of PTSD with valproate were located using a search protocol which was applied to the electronic databases CINAHL, EMBASE, MEDLINE and PSYCHINFO. A search of the National PTSD Centre Pilots Database and of the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register (CCDANCTR) were also conducted. Findings: We only found one single-blinded study, four open-label studies and three case reports. These data do not allow for robust conclusions because of the design of the studies which are of limited patient number and open to bias. However, the studies reported that valproate was generally effective for the treatment of symptoms of PTSD by reducing hyperarousal, improving irritability and anger outbursts and improving mood. Conclusions: The limited evidence base suggests that valproate can be effective as a monotherapy for the treatment of both PTSD and mood symptoms, A double blind controlled study should be the next step to robustly study the efficacy of valproate on the treatment of PTSD.

Item Type: Article
Additional information: Review
Uncontrolled keywords: meta-analysis; mood stabilisers; PTSD; review; valproate
Subjects: R Medicine > RC Internal medicine
Divisions: Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: Stephen Holland
Date Deposited: 19 Dec 2007 19:26
Last Modified: 21 May 2014 14:41
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