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A one -Year Multicenter Study of Simvastatin in the Treatment of Hypercholesterolemia

Graham, I., Robinson, K., Tomkin, G., Bradford, N.C., Wilkinson, P., Buckley, B., Seed, M., Marenah, C.B., Silas, J., Caplice, N., and others. (1994) A one -Year Multicenter Study of Simvastatin in the Treatment of Hypercholesterolemia. British Journal of Clinical Practice, 48 (5). pp. 231-235. ISSN 0007-0947. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)

Abstract

A 1-year prospective study was conducted in 475 hypercholesterolaemic men and women who received simvastatin monotherapy 10-40 mg daily for 3 months followed by additional lipid-lowering medication after this period, if necessary, to reach a target of plasma cholesterol <5.3 mmol/l. Of these, 403 subjects completed 1 year of follow-up. By the end of the 3-month monotherapy period, the following percentage mean changes were seen (with 95% confidence intervals): total cholesterol (TC) -31% (-30 to -32%), low-density lipoprotein cholesterol -39% (-38 to -40%), triglycerides -14% (-11 to -17%) and high-density lipoprotein cholesterol +12% (+11 to +14%). These levels were maintained for the remainder of the study. When subjects with a baseline TC of 6.5-7.8 mmol/l were considered (n=89), 42.7% achieved the target TC levels on simvastatin monotherapy alone. Additional hypolipidaemic medication had no Significant impact on plasma lipid and lipoprotein levels. Simvastatin was well tolerated both as monotherapy and in combination.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Sciences > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: P. Ogbuji
Date Deposited: 26 Jun 2009 15:36 UTC
Last Modified: 28 May 2019 13:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/20221 (The current URI for this page, for reference purposes)
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