Production of optically active lactones using cycloalkanone oxygenases

Lenn, Michael J. and Knowles, Christopher J. (1994) Production of optically active lactones using cycloalkanone oxygenases. Enzyme and Microbial Technology, 16 (11). pp. 964-969. ISSN 0141-0229. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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The oxidation of a number of bicyclic [n.2.0] ketones has been investigated using a novel bacterial isolate, Pseudomonas putida AS1. The organism was shown to promote similar Baeyer-Villiger type oxidations to the well-characterized organism, Acinetobacter sp. NCIMB 9871. A number of trends were noted with respect to the effect of different substitutions on the substrate on the regio- and stereoselectivity of the whole-cell-catalyzed reactions. These observations are of importance in defining the steric requirements for selectivity in cyclohexanone monooxygenase-catalyzed reactions. Pseudomonas putida AS1 is proposed as an alternative biocatalyst to the pathogenic Acinetobacter species.

Item Type: Article
Uncontrolled keywords: baeyer-villiger oxidation; biotransformation; cyclohexanone monooxygenase; bicyclic lactones; enantioselectivity
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: O.O. Odanye
Date Deposited: 12 Jul 2009 17:37
Last Modified: 28 May 2014 10:37
Resource URI: (The current URI for this page, for reference purposes)
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