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Getting the glycosylation right: Implications for the biotechnology industry

Jenkins, Nigel and Parekh, R.B. and James, David C. (1996) Getting the glycosylation right: Implications for the biotechnology industry. Nature Biotechnology, 14 (8). pp. 975-981. ISSN 1087-0156. (doi:10.1038/nbt0896-975) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19265)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
https://doi.org/10.1038/nbt0896-975

Abstract

Glycosylation is the most extensive of all the posttranslational modifications, and has important functions in the secretion, antigenicity and clearance of glycoproteins. In recent years major advances have been made in the cloning of glycosyltransferase enzymes, in understanding the varied biological functions of carbohydrates, and in the accurate analysis of glycoprotein heterogeneity. In this review we discuss the impact of these advances on the choice of a recombinant host cell line, in optimizing cell culture processes, and in choosing the appropriate level of glycosylation analysis for each stage of product development.

Item Type: Review
DOI/Identification number: 10.1038/nbt0896-975
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: R.F. Xu
Date Deposited: 04 Jun 2009 16:09 UTC
Last Modified: 09 Mar 2023 11:31 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/19265 (The current URI for this page, for reference purposes)

University of Kent Author Information

James, David C..

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