Skip to main content

Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses

Pickup, David M., Moss, Rob M., Qui, D., Newport, Robert J., Valappil, Sabeel P., Knowles, Jonathan C., Smith, Mark E. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, 130 (6). 064708. ISSN 0021-9606. (doi:10.1063/1.3076057) (KAR id:19150)

PDF Author's Accepted Manuscript
Language: English
Download (385kB)
[thumbnail of 1111.pdf]
This file may not be suitable for users of assistive technology.
Request an accessible format
Official URL:


Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.

Item Type: Article
DOI/Identification number: 10.1063/1.3076057
Additional information: Grant Number from STFC EP/C000714 EP/C000633 GR/T21080
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Funders: Science and Technology Facilities Council (
Depositing User: J.M. Smith
Date Deposited: 18 May 2009 12:58 UTC
Last Modified: 12 Jul 2022 10:39 UTC
Resource URI: (The current URI for this page, for reference purposes)
Newport, Robert J.:
  • Depositors only (login required):


Downloads per month over past year