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Clinical trial of the non-invasive recording of His-Purkinje system signals

Minelly, S. and Kelly, Stephen W. and Bahra, R. (1996) Clinical trial of the non-invasive recording of His-Purkinje system signals. In: Computers in Cardiology 1996. Computers in Cardiology . IEEE, pp. 449-452. ISBN 0-7803-3710-7. (doi:10.1109/CIC.1996.542570) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:18696)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1109/CIC.1996.542570

Abstract

A clinical system has been developed to detect His-Purkinje System (HPS) signals using surface recording technology and ensemble averaging. The reproducibility of this non-invasive methodology for recording Hisbundle signals in normal human volunteers has been. tested in a controlled clinical environment. The study recorded HPS signals from eight healthy volunteers, undosed, on placebo and following a single dose of beta-blocker (atenolol). This allowed the effects of the atenolol on the His-bundle intervals to be observed in a controlled fashion. A late notch (H) is recorded about 15ms before ventricular activation for most subjects in both dosed and un-dosed conditions. However in some subjects there is a distinct increase in the A-H interval with atenolol. This indicates that the H-notch originates from the conduction system.

Item Type: Book section
DOI/Identification number: 10.1109/CIC.1996.542570
Uncontrolled keywords: clinical trials; electrodes; electrocardiography; reproducibility of results; noise reduction; working environment noise; pulse amplifiers; circuits; signal restoration
Subjects: T Technology > TK Electrical engineering. Electronics. Nuclear engineering > TK7800 Electronics > TK7880 Applications of electronics
Q Science > QA Mathematics (inc Computing science) > QA 75 Electronic computers. Computer science
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculties > Sciences > School of Engineering and Digital Arts
Depositing User: F.D. Zabet
Date Deposited: 22 Jun 2009 10:55 UTC
Last Modified: 01 Aug 2019 08:31 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/18696 (The current URI for this page, for reference purposes)
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