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Drug incorporation and release of water soluble drugs from novel functionalised poly(glycerol adipate) nanoparticles

Puri, Sanyogita, Kallinteri, Paraskevi, Higgins, Sean, Hutcheon, Gillian A., Garnett, Martin C. (2008) Drug incorporation and release of water soluble drugs from novel functionalised poly(glycerol adipate) nanoparticles. Journal of Controlled Release, 125 (1). pp. 59-67. ISSN 0168-3659. (doi:10.1016/j.jconrel.2007.09.009) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:18624)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.jconrel.2007.09.009

Abstract

We have previously demonstrated the ability of poly(glycerol adipate) backbone (PGA) and PGA polymer backbone substituted with varying amounts of pendant C-18 chain length acyl groups to yield Dexamethasone phosphate DXMP loaded nanoparticles. The aim of this study was to obtain a deeper understanding of the underlying principles responsible for good drug incorporation and controlled release of drugs from poly (glycerol adipate) (PGA) nanoparticles. We compared the incorporation of the water soluble drugs DXMP and Cytosine arabinoside (CYT-ARA) in both unmodified and substituted PGA polymers. We investigated the effect of change in acyl group chain length and the degree of substitution on the physicochemical properties, drug loading and release of DXMP and CYT-ARA. Nanoparticles were prepared by the interfacial deposition technique and the simultaneous emulsification method.

A number of inter-related factors are responsible for producing particles with particular size, zeta potential, drug loading and release characteristics. Drug loading and release from nanoparticles are primarily influenced by the nature of interactions between the drug and polymers which in turn depend upon the type of drug used and the physical chemistry of the polymer.

Item Type: Article
DOI/Identification number: 10.1016/j.jconrel.2007.09.009
Additional information: 261GL Times Cited:1 Cited References Count:48
Uncontrolled keywords: nanoparticles anticancer drugs drug release hydrophilic drug controlled release shell-type nanoparticles plga nanoparticles nanoprecipitation method polymeric nanoparticles poly(ethylene oxide) sustained-release copolymer delivery encapsulation dexamethasone
Subjects: Q Science
R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Paraskevi Kallinteri
Date Deposited: 13 May 2009 09:46 UTC
Last Modified: 28 May 2019 13:57 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/18624 (The current URI for this page, for reference purposes)
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