Poly(amidoamine) Conjugates Containing Doxorubicin Bound via an Acid-Sensitive Linker.

Lavignac, Nathalie and Nicholls, Johanna and Ferruti, Paolo and Duncan, Ruth (2009) Poly(amidoamine) Conjugates Containing Doxorubicin Bound via an Acid-Sensitive Linker. Macromolecular Bioscience, 9 (5). pp. 480-487. ISSN 1616-5187. (doi:10.1002/mabi.200800163) (Full text available)

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Poly(amidoamine)s with amino pendant groups were prepared by hydrogen-transfer polyaddition of primary and secondary amines to bis-acrylamines. Dansyl cadaverine (DC) doxorubicin (Dox) were bound to the polymers via a cis-aconityl spacer to give conjugates containing 3 µg of DC per mg of polymer and 28 to 35 µg of Dox per mg of polymer. Release of DC and Dox at physiological and acidic pH varied from 0 to 35% over 48 h and was pH dependent. Although the ISA1Dox conjugate (IC50 = 6 µg Dox · mL-1) presented similar toxicity as the parent polymer without Dox, ISA23Dox showed increased toxicity (IC50 = 10 µg Dox · mL-1). These results suggest that ISA23Dox is able to release biologically active Dox in vitro and that this conjugate might be suitable for further development.

Item Type: Article
Additional information: Published online.
Uncontrolled keywords: drug delivery systems • nanotechnology • polyelectrolyte • stimuli-sensitive polymers • water-soluble polymers
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Nathalie Lavignac
Date Deposited: 13 May 2009 13:06
Last Modified: 19 Nov 2015 15:21
Resource URI: https://kar.kent.ac.uk/id/eprint/18607 (The current URI for this page, for reference purposes)
ORCiD (Lavignac, Nathalie): http://orcid.org/0000-0002-9259-7603
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