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The formation and substrate specificity of bacterial lactonases capable of enantioselective resolution of racemic lactones

Onakunle, O.A., Knowles, Christopher J., Bunch, Alan William (1997) The formation and substrate specificity of bacterial lactonases capable of enantioselective resolution of racemic lactones. Enzyme and Microbial Technology, 21 (4). pp. 245-251. ISSN 0141-0229. (doi:10.1016/S0141-0229(96)00267-0) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:18219)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/S0141-0229(96)00267-0

Abstract

The substrate specificities of epsilon-caprolactone hydrolase from Acinetobacter NCIMB 9871 and delta-valerolactone hydrolase from Pseudomonas NCIMB 9872 were investigated. Both lactonases showed activity toward six- and seven-membered ring lactones. delta-Valerolactone hydrolase exhibited enantioselectivity in its activity. It showed a preference for the R enantiomer of delta-decanolactone and delta-nonalactone whereas epsilon-caprolactone hydrolase showed little enantioselectivity toward the lactone substrates tested The delta-valerolactone hydrolase front Pseudomonas NCIMB 9872 may be useful for the resolution of racemic lactones, and hence may serve as an alternative route to chiral lactone synthesis.

Item Type: Article
DOI/Identification number: 10.1016/S0141-0229(96)00267-0
Uncontrolled keywords: chiral resolution; bacterial lactonases; delta-lactones
Subjects: Q Science
Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: M.A. Ziai
Date Deposited: 17 Apr 2009 15:24 UTC
Last Modified: 16 Nov 2021 09:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/18219 (The current URI for this page, for reference purposes)

University of Kent Author Information

Knowles, Christopher J..

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Bunch, Alan William.

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