A synthesis of alpha,alpha-disubstituted aryl-beta-ketoesters

Stefaniak, M.H. and Tinardon, F. and Wallis, John D. (1997) A synthesis of alpha,alpha-disubstituted aryl-beta-ketoesters. Synlett (6). pp. 677-678. ISSN 0936-5214. (The full text of this publication is not available from this repository)

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A generally applicable synthesis of alpha,alpha-disubstituted beta-ketoesters involving reaction of a substituted benzoyl chloride with methyl trimethylsilyl ketene acetal is described. Addition of boron trifluoride etherate is essential when the benzoyl chloride is nor substituted with a strongly electron withdrawing residue. The majority of experiments were conducted with the dimethylketene acetal but the process is equally applicable to the cyclohexaneketene acetal 5.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: T.J. Sango
Date Deposited: 12 May 2009 09:03
Last Modified: 12 May 2009 09:03
Resource URI: https://kar.kent.ac.uk/id/eprint/17973 (The current URI for this page, for reference purposes)
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