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Temperature induced aggregation in aqueous solution of a series of PEO-PPO-PEO copolymers

Gaisford, Simon, Beezer, Anthony E., Mitchell, John C., Bell, Paul C., Fakorede, Faluke, Finnie, Jill K., Williams, Stuart J. (1998) Temperature induced aggregation in aqueous solution of a series of PEO-PPO-PEO copolymers. International Journal of Pharmaceutics, 174 (1-2). pp. 39-46. ISSN 0378-5173. (doi:10.1016/S0378-5173(98)00223-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:17753)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/S0378-5173(98)00223-3

Abstract

The temperature induced aggregation phenomena of a series of poly(ethylene oxide)-poly(propylene oxide)poly(ethylene oxide) block copolymers (poloxamers) were investigated using dye incorporation UV spectroscopy, over a range of mass concentrations (0.1-15 mg ml(-1)). Initial experiments were performed using two different dyes (1,6-diphenyl-1,3,5-hexatriene (DPH) and I-2) so that the performance of each indicator for studying poloxamer aggregation could be determined. Subsequently, the onset temperatures (T-o) and temperature maxima (T-m) for the aggregation processes of 19 poloxamers were determined, using I-2 as an indicator. The aggregation temperature was observed to be dependent on both molecular mass and solution concentration for polymers comprising the same percent PEG, the aggregation temperature decreasing with increasing mass and/or increasing concentration.

Item Type: Article
DOI/Identification number: 10.1016/S0378-5173(98)00223-3
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: R.F. Xu
Date Deposited: 30 Jun 2009 10:37 UTC
Last Modified: 28 May 2019 13:55 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/17753 (The current URI for this page, for reference purposes)
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