Statistical issues in pharmacoepidemiological case-control studies

Ashby, Deborah and Smyth, Rosalind L. and Brown, Philip J. (1998) Statistical issues in pharmacoepidemiological case-control studies. Statistics in Medicine, 17 (15-16). pp. 1839-1850. ISSN 0277-6715. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Pharmacoepidemiology is the study of the use and the effect of drugs in large numbers of people. The work relies largely on standard epidemiological principles, which, applied in a new context, bring particular constraints and opportunities. In January 1994, a cluster of children with cystic fibrosis (CF) who developed strictures in the colon was reported. It was suggested that these may have been associated with high strength pancreatic enzyme preparations which had been introduced into use in these patients approximately one year previously. This hypothesis has been evaluated by a case-control study which confirms the association with high-strength pancreatic enzyme usage. The study is described and is used to illustrate statistical issues to provide a framework for future research in statistical methodology in pharmacoepidemiological case-control studies.

Item Type: Article
Additional information: Research Article. Conference on Statistical Issues in Pharmaceutical Development, Collaboration between Europe and the USA and the Regulation of Medicines from Research to Marketing De Montfort Univ, Dept Med Stat, Leicester, England, JUL 16-18, 1996
Subjects: Q Science > QA Mathematics (inc Computing science) > QA276 Mathematical statistics
Q Science > QA Mathematics (inc Computing science) > QA273 Probabilities
Q Science > QA Mathematics (inc Computing science)
R Medicine
Divisions: Faculties > Science Technology and Medical Studies > School of Mathematics Statistics and Actuarial Science > Statistics
Depositing User: I. Ghose
Date Deposited: 24 Nov 2009 12:46
Last Modified: 06 May 2014 14:28
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