Skip to main content

Determination of log P-app for drug transfer to microbial cellular systems via the Taylor-Aris modified diffusion technique

Montanari, Maria Luiza C., Montanari, Carlos A., Veloso, Dorila Pilow, Beezer, Anthony E., Mitchell, John C., Volpe, Pedro L. O. (1998) Determination of log P-app for drug transfer to microbial cellular systems via the Taylor-Aris modified diffusion technique. Quantitative Structure-Activity Relationships, 17 (2). pp. 102-108. ISSN 0931-8771. (doi:10.1002/(SICI)1521-3838(199804)17:02<102::AID-QSAR102>3.0.CO;2-T) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1002/(SICI)1521-3838(199804)1...

Abstract

Partitioning is a key process in QSAR studies. Experimental and calculated log P can be obtained. In the search for new methods of obtaining partition coefficients we have modified the Taylor-Aris diffusion technique to allow the direct measurement of log P within the cell system itself. This technique is applied successfully to two different cell systems and an extrathermodynamic equation between log P for Escherichia coli and Saccharomyces cerevisiae seems to be a promising way of obtaining this parameter directly from them.

Item Type: Article
DOI/Identification number: 10.1002/(SICI)1521-3838(199804)17:02<102::AID-QSAR102>3.0.CO;2-T
Additional information: Issue: 2 Document Type: Proceedings Paper
Uncontrolled keywords: Taylor-Aris diffusion technique; log PTA; Escherichia coli; Saccharomyces cerevisiae; QSRR
Subjects: R Medicine > R Medicine (General)
Q Science > QD Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: M.A. Ziai
Date Deposited: 29 Jun 2011 08:14 UTC
Last Modified: 04 Jun 2019 09:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/17453 (The current URI for this page, for reference purposes)
  • Depositors only (login required):