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Effect of ligand and solvent on chloride ion coordination in anti-tumour copper(I) diphosphine complexes: synthesis of [Cu(dppe)(2)]Cl and analogous complexes (dppe = 1,2-bis(diphenylphosphino)ethane)

Lewis, Jason S., Zweit, Jamal, Blower, Philip J. (1998) Effect of ligand and solvent on chloride ion coordination in anti-tumour copper(I) diphosphine complexes: synthesis of [Cu(dppe)(2)]Cl and analogous complexes (dppe = 1,2-bis(diphenylphosphino)ethane). Polyhedron, 17 (4). pp. 513-517. ISSN 0277-5387. (doi:10.1016/S0277-5387(97)00343-4) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1016/S0277-5387(97)00343-4

Abstract

Complexes formed between copper(I) and 1,2-bis(diphenylphosphino)ethane (L-1) have previously been isolated. as salts of the [CuL21](+) cation if only non-coordinating anions are present, or as [Cu2Cl2L31] if chloride is present. We describe the synthesis of [CuL21] the stoichiometry of which is confirmed by elemental analysis, FAB mass spectroscopy and conductivity. Polar solvents (water-ethanol mixtures) lead to isolation of the latter, whereas solvents of lower polarity (CHCl3, CH2Cl2) lead to isolation of the complexes containing coordinated chloride. Related ligands such as cis-1,2-bis(diphenylphosphino) ethene, 1,2-bis(diethylphosphino) ethane, 1,2-bis(dimethylphosphino) ethane and 1,2-bis(hydroxymethylphosphino) ethane, give salts [CuL2]Cl. This behaviour, and that of other 1,2-bisphosphine ligands, is rationalised in terms of competition between chloride and phosphine ligands for binding sites on the metal with the equilibrium position determined by solvent polarity, ligand structure and rigidity, and steric and electronic properties of the ligands.

Item Type: Article
DOI/Identification number: 10.1016/S0277-5387(97)00343-4
Uncontrolled keywords: copper; phosphine
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: M.A. Ziai
Date Deposited: 03 Apr 2009 22:53 UTC
Last Modified: 28 May 2019 13:55 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/17420 (The current URI for this page, for reference purposes)
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