Pharmaceutical microcalorimetry: applications to long-term stability studies

Beezer, Anthony E. and Gaisford, Simon and Hills, Andrew K. and Willson, Richard J. and Mitchell, John C. (1999) Pharmaceutical microcalorimetry: applications to long-term stability studies. International Journal of Pharmaceutics, 179 (2). pp. 159-165. ISSN 0378-5173. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Calorimetry has been a mainstay of stability analyses for some time in the form of differential scanning microcalorimetry (DSC). This technique exploits high (relatively) temperature studies of pure materials and of formulations to accelerate any degradation or interactions. The behaviour of the material at storage or ambient conditions is then estimated via extrapolation from the Arrhenius equation. Recent developments in isothermal microcalorimetry allow the direct determination of both kinetic and thermodynamic parameters for long, slow reactions from studies conducted at appropriate temperatures and under designated environmental control (pH, pO(2), RH etc.). This review introduces the kinetic analysis of microcalorimetric data and, through selected examples, shows applications of the method. (C) 1999 Elsevier Science B.V. All rights reserved.

Item Type: Article
Uncontrolled keywords: isothermal microcalorimetry; kinetics; stability
Subjects: Q Science > QD Chemistry
Q Science > QC Physics
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: M. Nasiriavanaki
Date Deposited: 13 Jul 2009 07:44
Last Modified: 09 May 2014 08:03
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