The role of locus coeruleus in the regulation of cognitive performance

Usher, Marius and Cohen, Jonathan D. and Servan-Schreiber, David and Rajkowski, Janusz and Aston-Jones, Gary (1999) The role of locus coeruleus in the regulation of cognitive performance. Science, 283 (5401). pp. 549-554. ISSN 0036-8075. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Noradrenergic locus coeruleus (LC) neurons were recorded in monkeys performing a visual discrimination task, and a computational model was developed addressing the role of the LC brain system in cognitive performance. Changes in spontaneous and stimulus-induced patterns of LC activity correlated closely with fluctuations in behavioral performance. The model explains these fluctuations in terms of changes in electrotonic coupling among LC neurons and predicts improved performance during epochs of high coupling and synchronized LC firing. Cross correlations of simultaneously recorded LC neurons confirmed this prediction, indicating that electronic coupling in LC may play an important role in attentional modulation and the regulation of goat-directed versus exploratory behaviors.

Item Type: Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Social Sciences > School of Psychology
Depositing User: F.D. Zabet
Date Deposited: 20 Mar 2009 11:14
Last Modified: 02 May 2014 10:41
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