3-D reconstruction of macroscopic optical brain slice images

Colchester, Alan C. F. and Ourselin, Sébastien and Zhu, Yonggen and Bardinet, Eric and He, Yang and Roche, Alexis and Al-Sarraj, Safa and Nailon, Bill and Ironside, James and Ayache, Nicholas (2000) 3-D reconstruction of macroscopic optical brain slice images. In: 3rd International Conference on Medical Image Computing and Computer-Assisted Intervention, Pittsburgh, Pennsylvania. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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We present a method for reconstruction of macroscopic optical images of post-mortem brain slices to form a 3-D volume. This forms a key part of a series of procedures to allow postmortem findings to be accurately registered with MR images, and more generally provides a method for 3-D mapping of the distribution of pathological changes throughout the brain. In this preliminary work, four brains from a study of Creutzfeldt-Jakob disease were examined. After brain fixation, the pathologist cut coronal slices several nun thick through the brain. The anterior and posterior faces of each slice were photographed. We show that the 2-D co-registration of each such pair of images was most effectively obtained if the slice was placed in a jig before photographing. Fiducials. on the jig were detected automatically and point-based rigid registration computed. For co-registration between slices, i.e., across a single cut, an intensity-based method for 2-D non-rigid registration is used which provided satisfactory results. By propagating the 2-D registrations through the volume and using the known slice thickness, the 3-D volume was reconstructed.

Item Type: Conference or workshop item (Other)
Uncontrolled keywords: registration; magnetic resonance image-to-pathology correlation; Creutzfeldt-Jakob disease
Subjects: Q Science > QA Mathematics (inc Computing science) > QA 75 Electronic computers. Computer science
Divisions: Faculties > Science Technology and Medical Studies > School of Computing > Theoretical Computing Group
Depositing User: P. Ogbuji
Date Deposited: 03 Apr 2009 16:53
Last Modified: 30 Apr 2014 15:38
Resource URI: https://kar.kent.ac.uk/id/eprint/16293 (The current URI for this page, for reference purposes)
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