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Activation of the interleukin 2 receptor: a possible role for tyrosine phosphatases

Ellery, Jonathan M., Kempshall, Sarah J., Nicholls, Peter J. (2000) Activation of the interleukin 2 receptor: a possible role for tyrosine phosphatases. Cellular Signalling, 12 (6). pp. 367-373. ISSN 0898-6568. (doi:10.1016/S0898-6568(00)00085-1) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:16063)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/S0898-6568(00)00085-1

Abstract

Engagement of interleukin-2 (IL-2) mediates the heterodimeridation of the common beta chain (beta(c)) and common gamma chain (gamma(c)) of the IL-2 receptor (IL-2R). This is sufficient and necessary for receptor activation and signal transduction. It is generally held that the IL-2R is activated by the trans-activity of the protein tyrosine kinases (PTKs) Jak1 and Jak3 associated with beta(c) and gamma(c) respectively. Transduction of proliferative signals requires Jak3 activity. A Jak3 independent signalling pathway involving p56(lck), generating anti-apoptotic signals, can be observed and requires the PROX domain of gamma(c). p56(lck) can be activated by dephosphorylation of an inhibitory carboxyl terminal phosphorylated tyrosine residue (Y505). We propose that this is mediated by a PROX domain associated protein tyrosine phosphatase (PTP). Activation of p56(lck) alone is insufficient for transduction of proliferative signals and thus works in concert with Jak3 mediated receptor activation. This indicates that both gamma(c) domains are vital for signal transduction.

Item Type: Article
DOI/Identification number: 10.1016/S0898-6568(00)00085-1
Uncontrolled keywords: interleukin-2; IL-2R; phosphatase; lck; Jak3; dephosphorylation
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: O.O. Odanye
Date Deposited: 19 May 2009 01:58 UTC
Last Modified: 16 Nov 2021 09:54 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/16063 (The current URI for this page, for reference purposes)

University of Kent Author Information

Nicholls, Peter J..

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