Bioactive functional materials: a perspective on phosphate-based glasses

Abou Neel, Ensanya A. and Pickup, David M. and Valappil, Sabeel P. and Newport, Robert J. and Knowles, Jonathan C. (2009) Bioactive functional materials: a perspective on phosphate-based glasses. Journal of Materials Chemistry, 19 (6). pp. 690-701. ISSN 0959-9428. (doi: (Full text available)

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The general trend in biomaterials is to use and employ materials that play an active role in tissue regeneration rather than passive and inert materials. Therefore, understanding how a material interacts with the surrounding environments, including cells and tissue fluid, allows material design to be tailored so that implants can be constructed to promote a specific biological response, helping them better perform their function. This class of materials has been described as the "Third Generation" of biomaterials. Phosphate based glasses fall into this category and it has been shown that the properties of these glasses can be tuned via their composition according to the desired end application. These glasses can be prepared as melt-quenched or sol-gel bulk form suitable for potential hard tissue engineering applications and as vehicles for antimicrobial agents. They can also be prepared as fibres suitable for soft tissue engineering applications such as those involving muscle, ligaments, and tendon, where, like the fibres, the tissue has a high degree of anisotropy.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: J.M. Smith
Date Deposited: 14 May 2009 14:39 UTC
Last Modified: 18 Jul 2014 10:51 UTC
Resource URI: (The current URI for this page, for reference purposes)
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