Skip to main content

Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension

Lai, Ying-Ju, Pullamsetti, Soni Savai, Dony, Eva, Weissmann, Norbert, Butrous, Ghazwan S., Banat, Gamal-Andre, Ghofrani, Hossein A., Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T. and others. (2008) Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension. American Journal of Respiratory and Critical care Medicine, 178 (2). 188 -196. ISSN 1073-449X. (doi:10.1164/rccm.200710-1519OC) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:14712)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1164/rccm.200710-1519OC

Abstract

Rationale Iloprost is effective for the treatment of pulmonary hypertension. It acts through elevation of CAMP by binding to the prostacyclin receptor (IP receptor). However, there is evidence that patients with severe pulmonary hypertension have decreased expression of the IP receptor in the remodeled pulmonary arterial smooth muscle.

Conclusions: Iloprost mediates vasodilatory functions via the EP4 receptor in the case of low IP receptor expression associated with pulmonary arterial hypertension. This is a previously unrecognized mechanism for iloprost, and illustrates that the EP4 receptor may be a novel therapeutic approach for the treatment of pulmonary arterial hypertension.

Item Type: Article
DOI/Identification number: 10.1164/rccm.200710-1519OC
Uncontrolled keywords: prostanoid EP4 receptor; iloprost; pulmonary artery hypertension
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Sciences > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: Louise Dorman
Date Deposited: 18 Apr 2009 10:48 UTC
Last Modified: 28 May 2019 13:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/14712 (The current URI for this page, for reference purposes)
  • Depositors only (login required):