Myo1c is designed for the adaptation response in the inner ear

Batters, Christopher, Arthur, Christopher P., Lin, Abel, Porter, Jessica, Geeves, Michael A., Milligan, Ronald A., Molloy, Justin E., Coluccio, Lynne M. (2004) Myo1c is designed for the adaptation response in the inner ear. Embo Journal, 23 (7). pp. 1433-40. ISSN 0261-4189. (doi:10.1038/sj.emboj.7600169) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:13200)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/ 10.1038/sj.emboj.7600169

Abstract

The molecular motor, Myo1c, a member of the myosin family, is widely expressed in vertebrate tissues. Its presence at strategic places in the stereocilia of the hair cells in the inner ear and studies using transgenic mice expressing a mutant Myo1c that can be selectively inhibited implicate it as the mediator of slow adaptation of mechanoelectrical transduction, which is required for balance. Here, we have studied the structural, mechanical and biochemical properties of Myo1c to gain an insight into how this molecular motor works. Our results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load.

Item Type:	Article
DOI/Identification number:	10.1038/sj.emboj.7600169
Additional information:	0261-4189 (Print) Journal Article
Uncontrolled keywords:	Adaptation, Biological Adenosine Diphosphate/metabolism Animals Cochlea/physiology Cryoelectron Microscopy Hair Cells/cytology/metabolism Mechanotransduction, Cellular/physiology Mice Models, Molecular Myosins/chemistry/*metabolism/ultrastructure Rats Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Stress, Mechanical
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Michael Geeves
Date Deposited:	29 May 2009 06:00 UTC
Last Modified:	05 Nov 2024 09:46 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/13200 (The current URI for this page, for reference purposes)

University of Kent Author Information

Geeves, Michael A..

Creator's ORCID:	https://orcid.org/0000-0002-9364-8898
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