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The Genetic Control of the Formation and Propagation of the [PSI+] Prion of Yeast

Tuite, Mick F., Cox, Brian S. (2007) The Genetic Control of the Formation and Propagation of the [PSI+] Prion of Yeast. Prion, 1 (2). pp. 101-109. ISSN 1933-6896. (doi:10.4161/pri.1.2.4665) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12953)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.4161/pri.1.2.4665

Abstract

It is over 40 years since it was first reported that the yeast Saccahromyces cerevisiae contains two unusual cytoplasmic ‘genetic’ elements: [PSI+] and [URE3]. Remarkably the underlying determinants are protein-based rather than nucleic acid-based, i.e., that they are prions, and we have already learned much about their inheritance and phenotypic effects from the application of ‘classical’ genetic studies alongside the more modern molecular, cellular and biochemical approaches. Of particular value has been the exploitation of chemical mutagens and ‘antagonistic’ mutants which directly affect the replication and/or transmission of yeast prions. In this chapter we describe what has emerged from the application of classical and molecular genetic studies, to the most intensively studied of the three native yeast prions, the [PSI+] prion.

Item Type: Article
DOI/Identification number: 10.4161/pri.1.2.4665
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences > Protein Science Group
Depositing User: Michael Tuite
Date Deposited: 16 Sep 2008 07:27 UTC
Last Modified: 06 May 2020 03:03 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12953 (The current URI for this page, for reference purposes)
Tuite, Mick F.: https://orcid.org/0000-0002-5214-540X
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