Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution

Griffin, Darren K. and Robertson, Lindsay and Tempest, Helen G. and Vignal, Alain and Fillon, Valerie and Crooijmans, Richard P.M.A. and Groenen, Martien A. M. and Deryusheva, Svetlana and Gaginskaya, Elena and Carre, Wilfrid and Waddington, David and Talbot, Richard and Volker, Martin and Masabanda, Julio S. and Burt, David W. (2008) Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution. BMC Genomics, 9 (Article 168). p. 168. ISSN 1471-2164 . (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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BACKGROUND: Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny. The availability of the complete sequence of the chicken genome has initiated the development of detailed genomic information in other birds including turkey, an agriculturally important species where mapping has hitherto focused on linkage with limited physical information. No molecular study has yet examined conservation of avian microchromosomes, nor differences in copy number variants (CNVs) between birds. RESULTS: We present a detailed comparative cytogenetic map between chicken and turkey based on reciprocal chromosome painting and mapping of 338 chicken BACs to turkey metaphases. Two inter-chromosomal changes (both involving centromeres) and three pericentric inversions have been identified between chicken and turkey; and array CGH identified 16 inter-specific CNVs. CONCLUSION: This is the first study to combine the modalities of zoo-FISH and array CGH between different avian species. The first insight into the conservation of microchromosomes, the first comparative cytogenetic map of any bird and the first appraisal of CNVs between birds is provided. Results suggest that avian genomes have remained relatively stable during evolution compared to mammalian equivalents.

Item Type: Article
Additional information: Research Article 1471-2164-9-168 1471-2164
Uncontrolled keywords: Animals Chickens Chromosome Mapping Chromosomes, Artificial, Bacterial Color Cytogenetics Evolution, Molecular Genome Genomics Humans In Situ Hybridization, Fluorescence Metaphase Oligonucleotide Array Sequence Analysis Sequence Analysis, DNA Turkeys
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Darren Griffin
Date Deposited: 24 Feb 2009 09:36
Last Modified: 17 Jul 2014 10:12
Resource URI: https://kar.kent.ac.uk/id/eprint/12499 (The current URI for this page, for reference purposes)
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