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The cytogenetics of preimplantation human development: insights provided by traditional and novel techniques

Tempest, Helen G., Griffin, Darren K. (2005) The cytogenetics of preimplantation human development: insights provided by traditional and novel techniques. Chromosoma, 114 (4). pp. 295-299. ISSN 0009-5915. (doi:10.1007/s00412-005-0340-x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12494)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1007/s00412-005-0340-x

Abstract

Our understanding of the incidence and origin of chromosome abnormalities in human preimplantation embryos is very limited due to the necessary ethical constraints involved in studying such material and the limited data ultimately produced. Several studies have addressed this issue, however, using techniques such as interphase fluorescence in situ hybridisation, modified G-banding preparation and the use of single-cell comparative genomic hybridisation (CGH). This review discusses the use of these techniques in assessing chromosome abnormalities in this, the earliest of human developmental stages. In addition, the prospects for the clinical use of CGH are discussed.

Item Type: Article
DOI/Identification number: 10.1007/s00412-005-0340-x
Additional information: 10.1007/s00412-005-0340-x 0009-5915
Uncontrolled keywords: Aneuploidy Blastocyst Cytogenetics Humans In Situ Hybridization, Fluorescence Interphase Nucleic Acid Hybridization
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Darren Griffin
Date Deposited: 12 Sep 2008 22:51 UTC
Last Modified: 16 Nov 2021 09:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12494 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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