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The genetic and cytogenetic basis of male infertility

Griffin, Darren K., Finch, Katie A. (2005) The genetic and cytogenetic basis of male infertility. Human Fertility, 8 (1). pp. 19-26. ISSN 1464-7273. (doi:10.1080/14647270400016407) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12490)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1080/14647270400016407

Abstract

Despite the difficulties in determining the relative maternal vs. paternal contributions to infertility it is often suggested that a male factor problem is implicated in 50% of cases. This review is concerned specifically with male fertility disorders that have a clearly defined genetic component. The genetic causes of infertility can be broken down into Y chromosome deletions (specifically deletions in the AZF a, b, and c regions), single gene disorders (particularly those relating to the CFTR gene), multifactorial causes and chromosome abnormalities. Chromosome abnormalities can be numerical (such as trisomy--full blown or mosaic) or structural (such as inversions or translocations). Of especial interest at present is the incidence of levels of numerical chromosome abnormalities in the sperm of infertile men; prospects for screening sperm for such abnormalities are discussed.

Item Type: Article
DOI/Identification number: 10.1080/14647270400016407
Additional information: J46514P8733105M8 1464-7273
Uncontrolled keywords: Angelman Syndrome Chromosome Aberrations Chromosomes, Human, Y Cystic Fibrosis Humans Infertility, Male Male Myotonic Dystrophy Prader-Willi Syndrome
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Darren Griffin
Date Deposited: 06 Sep 2008 08:35 UTC
Last Modified: 16 Nov 2021 09:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12490 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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