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The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs

Tempest, Helen G., Homa, Sheryl T., Dalakiouridou, Maria, Christopikou, Dimitra, Wright, David B., Zhai, Xiao-Ping, Griffin, Darren K. (2004) The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs. Reproductive Biology and Endocrinology, (2). p. 82. (doi:10.1186/1477-7827-2-82) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12489)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1186/1477-7827-2-82

Abstract

BACKGROUND: The association between infertility and sperm disomy is well documented. Results vary but most report that men with severely compromised semen parameters have a significantly elevated proportion of disomic sperm. The relationship between individual semen parameters and segregation of specific chromosome pairs is however less well reported as is the variation of disomy levels in individual men. METHODS: In order to address these questions the technique of fluorescent in-situ hybridisation (FISH) was utilised to determine the disomy levels of chromosomes X, Y and 21 in 43 sperm samples from 19 infertile males. The results generated from this study were analysed using logistic regression. RESULTS: In this study we compared levels of sperm concentration, motility and morphology with levels of sperm disomy for chromosome 21 and the sex chromosomes. Our results suggest that there is considerable variation in disomy levels for certain men. They also suggest that oligozoospermic males have significantly elevated levels of sex chromosome disomy but not disomy 21; they suggest that severe asthenozoospermic males have significantly elevated levels of disomy 21 but not sex chromosome disomy. Surprisingly, severe teratozoopsermic males appeared to have significantly lower levels of sperm disomy for both the sex chromosomes and chromosome 21. CONCLUSION: We suggest that the association between sex chromosome disomy and oligozoospermia may be due to reduced recombination in the XY pairing region and discuss the relevance of our findings for the correlations between sperm disomy and sperm motility and morphology.

Item Type: Article
DOI/Identification number: 10.1186/1477-7827-2-82
Additional information: 1477-7827-2-82 1477-7827
Uncontrolled keywords: Chromosomes, Human, Pair 21 Chromosomes, Human, X Chromosomes, Human, Y Humans In Situ Hybridization, Fluorescence Infertility, Male Male Regression Analysis Semen Sperm Count Spermatozoa Uniparental Disomy
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Darren Griffin
Date Deposited: 02 Oct 2008 16:13 UTC
Last Modified: 16 Nov 2021 09:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12489 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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