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The relationship between male infertility and increased levels of sperm disomy

Tempest, Helen G., Griffin, Darren K. (2004) The relationship between male infertility and increased levels of sperm disomy. Cytogenetic and Genome Research, 107 (1-2). pp. 83-94. ISSN 1424-8581. (doi:10.1159/000079575) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12488)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1159/000079575

Abstract

Sperm chromosome abnormalities cut across a number of areas relevant to ICC XV. The association between increased levels of sperm aneuploidy (usually disomy) and male infertility has implications for the sessions on reproduction, sex chromosomes, aneuploidy and meiosis and was, to the best of our knowledge, first reported in 1995. Since then most studies have reported similar increases of varying degrees but, despite this, a small number of laboratories have presented results that demonstrate no significant association. The purpose of this article is to review the state of the art in this area and to speculate as to reasons for the differences in reports from different laboratories. The findings are broken down by chromosome with studies of the sex chromosomes being broken down further to indicate meiotic stages of origin. We conclude that comparisons are difficult to make since many studies do not clearly define patient and control groups. Nevertheless, despite these and other differences (such as scoring criteria, technical differences, demographics, etc.), the consensus in the literature is that a strong correlation exists between sperm aneuploidy and male infertility. The nature of that relationship will be further defined when andrological criteria are more closely taken into account and protocols for preparation and scoring are standardised.

Item Type: Article
DOI/Identification number: 10.1159/000079575
Additional information: 15305060 1424-859X
Uncontrolled keywords: Humans Infertility Male Spermatozoa Uniparental Disomy
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Darren Griffin
Date Deposited: 01 Oct 2008 14:56 UTC
Last Modified: 23 Jan 2020 04:02 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12488 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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