FDG-pet findings in the Wernicke-Korsakoff syndrome

Reed, Laurence J. and Lasserson, Dan and Marsden, Paul K. and Stanhope, Nicola and Stevens, Tom and Bello, Fernando and Kingsley, Derek and Colchester, Alan C. F. and Kopelman, Michael D. (2003) FDG-pet findings in the Wernicke-Korsakoff syndrome. Cortex, 39 (4-5). pp. 1027-1045. ISSN 0010-9452. (doi:https://doi.org/10.1016/S0010-9452(08)70876-1 ) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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This study reports FDG-PET findings in Wernicke-Korsakoff patients. Twelve patients suffering amnesia arising from the Korsakoff syndrome were compared with 10 control subjects without alcohol-related disability. Subjects received [F-18]-fluorodeoxyglucose (FDG-PET) imaging as well as neuropsychological assessment and high-resolution MR imaging with volumetric analysis. Volumetric MRI analysis had revealed thalamic and mamillary body atrophy in the patient group as well as frontal lobe atrophy with relative sparing of medial temporal lobe structures. Differences in regional metabolism were identified using complementary region of interest (ROI) and statistical parametric mapping (SPM) approaches employing either absolute methods or a reference region approach to increase statistical power. In general, we found relative hypermetabolism in white matter and hypometabolism in subcortical grey matter in Korsakoff patients. When FDG uptake ratios were examined with occipital lobe metabolism as covariate reference region, Korsakoff patients showed widespread bilateral white matter hypermetabolism on both SPM and ROI analysis. When white matter metabolism was the reference covariate, Korsakoff patients showed relative hypometabolism in the diencephalic grey matter, consistent with their known underlying neuropathology, and medial temporal and retrosplenial hypometabolism, interpreted as secondary metabolic effects within the diencephalic-limbic memory circuits. There was also evidence of a variable degree of more general frontotemporal neocortical hypometabolism on some, but not all, analyses.

Item Type: Article
Additional information: IN FILE
Uncontrolled keywords: Wernicke-Korsakoff amnesia memory disorder frontal lobes PET
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculties > Sciences > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: M.P. Stone
Date Deposited: 12 Sep 2008 10:35 UTC
Last Modified: 14 Jul 2014 12:29 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12256 (The current URI for this page, for reference purposes)
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