Efficacy of memantine on behavioral and psychological symptoms related to dementia: A systematic meta-analysis

Maidment, Ian D. and Fox, Chris G. and Boustani, Malaz and Rodriguez, Jorge and Brown, Ruth C. and Katona, Cornelius (2008) Efficacy of memantine on behavioral and psychological symptoms related to dementia: A systematic meta-analysis. Annals of Pharmacotherapy, 42 (1). pp. 32-38. ISSN 1060-0280. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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BACKGROUND: The behavioral and psychological symptoms related to dementia (BPSD) are difficult to manage and are associated with adverse patient outcomes. OBJECTIVE: To systematically analyze the data on memantine in the treatment of BPSD. METHODS: We searched MEDLINE, EMBASE, Pharm-line, the Cochrane Centre Collaboration, www.clinicaltrials.gov, www.controlled-trials.com, and PsycINFO (1966-July 2007). We contacted manufacturers and scrutinized the reference sections of articles identified in our search for further references, including conference proceedings. Two researchers (IM and CF) independently reviewed all studies identified by the search strategy. We included 6 randomized, parallel-group, double-blind studies that rated BPSD with the Neuropsychiatric Inventory (NPI) in our meta-analysis. Patients had probable Alzheimer's disease and received treatment with memantine for at least one month. Overall efficacy of memantine on the NPI was established with a t-test for the average difference between means across studies, using a random effects model. RESULTS: Five of the 6 studies identified had NPI outcome data. In these 5 studies, 868 patients were treated with memantine and 882 patients were treated with placebo. Patients on memantine improved by 1.99 on the NPI scale (95% CI -0.08 to -3.91; p = 0.041) compared with the placebo group. CONCLUSIONS: Initial data appear to indicate that memantine decreases NPI scores and may have a role in managing BPSD. However, there are a number of limitations with the current data; the effect size was relatively small, and whether memantine produces significant clinical benefit is not clear.

Item Type: Article
Uncontrolled keywords: Alzheimer's disease dementia memantine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: M.P. Stone
Date Deposited: 27 Mar 2009 17:13
Last Modified: 13 May 2014 09:32
Resource URI: https://kar.kent.ac.uk/id/eprint/12200 (The current URI for this page, for reference purposes)
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