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An array of brain protease activities and their modulation by the toxic effects of cyanamide

Bonner, Adrian B., Ahmed, Sohail, Mantle, David, Preedy, Victor R. (2006) An array of brain protease activities and their modulation by the toxic effects of cyanamide. Toxicology, 226 (1). pp. 62-63. ISSN 0300-483X. (doi:10.1016/j.tox.2006.05.082) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12028)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.tox.2006.05.082

Abstract

Brain proteolytic enzymes have been implicated in a

a few components such as the ATP-ubiquitin pathway.

proteolytic enzyme types, to address the hypothesis that

dosed maleWistar rats (approximately 0.1 kg BW) with

of aldehyde dehydrogenase (ALDH) (0.5 mmol/kg BW;

Using fluorimetry, we measured the activities

(ALAAP), arginyl-aminopeptidase (ARGAP), leucylaminopeptidase

IV (DIA-IV), tripeptidyl aminopetidase (TRI-AP) and

enzymes cathepsins B (CATHB), D (CATHD),

I (DIA-I) and II (DIA-II) and proteasomal

activities (Table 1).

(Table 1). The highest activity was found in arginyl

low. In response to cyanamide dosage in vivo, there were

DIA-IV (P < 0.05). There were also reductions in

In conclusions, impaired proteolysis may contribute

to, or reflect, the cellular toxicity of cyanamide.

Item Type: Article
DOI/Identification number: 10.1016/j.tox.2006.05.082
Additional information: This item is a Meeting abstract.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > University wide - Teaching/Research Groups > Centre for Cognitive Neuroscience and Cognitive Systems
Depositing User: M.P. Stone
Date Deposited: 08 Aug 2009 10:44 UTC
Last Modified: 28 May 2019 13:48 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12028 (The current URI for this page, for reference purposes)
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