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The discriminative stimulus properties of self-administered ethanol are mediated by GABA(A) and NMDA receptors in rats.

Hodge, Clyde W., Cox, Amy A., Bratt, Alison M., Camarini, Rosana, Kelley, Stephen P., Mehmert, Kirstin K., Nannini, Michelle A., Olive, M. Foster (2001) The discriminative stimulus properties of self-administered ethanol are mediated by GABA(A) and NMDA receptors in rats. Psychopharmacology, 154 . pp. 13-22. (doi:10.1007/s002130000619) (KAR id:11702)

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http://dx.doi.org/10.1007/s002130000619

Abstract

RATIONALE:

METHODS:

RESULTS:

CONCLUSIONS:

Self-administered ethanol substituted for and potentiated the stimulus effects of investigator-administered ethanol, suggesting that the discriminative stimulus effects of self-administered ethanol are similar to those produced by investigator-administered ethanol. Self-administered ethanol enhanced the ethanol-like discriminative stimulus effects of MK-801 and pentobarbital, which suggests that the discriminative stimulus effects of self-administered ethanol are mediated by NMDA and GABAA receptors.

Item Type: Article
DOI/Identification number: 10.1007/s002130000619
Subjects: R Medicine > RM Therapeutics. Pharmacology
Q Science > QP Physiology (Living systems)
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Alison Kelley
Date Deposited: 29 Jun 2011 17:07 UTC
Last Modified: 28 May 2019 13:48 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/11702 (The current URI for this page, for reference purposes)
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