de Abreu, Breno U., Almeida, Renata G., Silveira, Ana L. C., Matos, Leonardo A., Oliveira, Willian X. C., Araujo, Maria H., Ramos, Victor F. S., Menna-Barreto, Rubem F. S., Nichinde, Chandrakant B., Fantuzzi, Felipe, and others. (2026) Synthesis of Naphthoquinones by Pd-Catalyzed Heck–Matsuda Arylation of Lapachol. European Journal of Organic Chemistry, . ISSN 1434-193X. (doi:10.1002/ejoc.70790) (KAR id:115633)
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Language: English 
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| Official URL: https://doi.org/10.1002/ejoc.70790 |
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Abstract
Direct Heck–Matsuda arylation of lapachol provides rapid access to structurally diverse naphthoquinones under homogeneous and heterogeneous palladium catalysis. The methodology features broad substrate scope, gram-scale applicability, and unambiguous structural assignment by single-crystal X-ray diffraction, providing an efficient platform for the diversification of quinones.
| Item Type: | Article |
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| DOI/Identification number: | 10.1002/ejoc.70790 |
| Uncontrolled keywords: | Chagas disease; Heck–matsuda reaction; lapachol; naphthoquinones; palladium coupling |
| Subjects: | Q Science > QD Chemistry |
| Institutional Unit: | Schools > School of Natural Sciences > Chemistry and Forensic Science |
| Former Institutional Unit: |
There are no former institutional units.
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| Funders: |
Coordenação de Aperfeicoamento de Pessoal de Nível Superior (https://ror.org/00x0ma614)
Royal Society (https://ror.org/03wnrjx87) Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (https://ror.org/05k49za97) National Council for Scientific and Technological Development (https://ror.org/03swz6y49) |
| Depositing User: | Felipe Fantuzzi |
| Date Deposited: | 18 Jun 2026 20:32 UTC |
| Last Modified: | 18 Sep 2026 13:28 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/115633 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Fantuzzi, Felipe.
| Creator's ORCID: |
 https://orcid.org/0000-0002-8200-8262
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