Stadhouders, Ralph, van den Heuvel, Anita, Kolovos, Petros, Jorna, Ruud, Leslie, Kris D., Grosveld, Frank, Soler, Eric (2012) Transcription regulation by distal enhancers. Who's in the loop? Transcription, 3 (4). pp. 181-186. ISSN 2154-1264. (doi:10.4161/trns.20720) (KAR id:115052)
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| Official URL: https://doi.org/10.4161/trns.20720 |
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Abstract
Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.
| Item Type: | Article |
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| DOI/Identification number: | 10.4161/trns.20720 |
| Uncontrolled keywords: | enhancer, Myb; chromatin looping; chromosome conformation capture; long-range interactions; transcription elongation; transcription regulatory networks |
| Institutional Unit: | Schools > Kent and Medway Medical School |
| Former Institutional Unit: |
There are no former institutional units.
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| Depositing User: | Kris Leslie |
| Date Deposited: | 13 May 2026 23:47 UTC |
| Last Modified: | 18 Jul 2026 03:21 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/115052 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Leslie, Kris D..
| Creator's ORCID: |
 https://orcid.org/0009-0007-9371-6890
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| CReDIT Contributor Roles: |
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