Ping, Zhen, Chen, Si, Hermans, Sjoerd J F, Kenswil, Keane J G, Feyen, Jacqueline, van Dijk, Claire, Bindels, Eric M J, Mylona, Athina M, Adisty, Niken M, Hoogenboezem, Remco M, and others. (2019) Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. Leukemia, 33 (2). pp. 536-541. ISSN 1476-5551. (KAR id:115043)
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Abstract
Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS. Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis. Activation of NF-κB attenuates HSPC numbers and function ex vivo.
| Item Type: | Article |
|---|---|
| Institutional Unit: | Schools > Kent and Medway Medical School |
| Former Institutional Unit: |
There are no former institutional units.
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| Funders: | Dutch Research Council (https://ror.org/04jsz6e67) |
| Depositing User: | Athina Mylona |
| Date Deposited: | 13 May 2026 22:22 UTC |
| Last Modified: | 13 May 2026 22:22 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/115043 (The current URI for this page, for reference purposes) |
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