Kenswil, Keane Jared Guillaume, Jaramillo, Adrian Christopher, Ping, Zhen, Chen, Si, Hoogenboezem, Remco Michiel, Mylona, Maria Athina, Adisty, Maria Niken, Bindels, Eric Moniqué Johannes, Bos, Pieter Koen, Stoop, Hans, and others. (2018) Characterization of Endothelial Cells Associated with Hematopoietic Niche Formation in Humans Identifies IL-33 As an Anabolic Factor. Cell reports, 22 (3). pp. 666-678. ISSN 2211-1247. (KAR id:115038)
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Abstract
Bone marrow formation requires an orchestrated interplay between osteogenesis, angiogenesis, and hematopoiesis that is thought to be mediated by endothelial cells. The nature of the endothelial cells and the molecular mechanisms underlying these events remain unclear in humans. Here, we identify a subset of endoglin-expressing endothelial cells enriched in human bone marrow during fetal ontogeny and upon regeneration after chemotherapeutic injury. Comprehensive transcriptional characterization by massive parallel RNA sequencing of these cells reveals a phenotypic and molecular similarity to murine type H endothelium and activation of angiocrine factors implicated in hematopoiesis, osteogenesis, and angiogenesis. Interleukin-33 (IL-33) was significantly overexpressed in these endothelial cells and promoted the expansion of distinct subsets of hematopoietic precursor cells, endothelial cells, as well as osteogenic differentiation. The identification and molecular characterization of these human regeneration-associated endothelial cells is thus anticipated to instruct the discovery of angiocrine factors driving bone marrow formation and recovery after injury.
| Item Type: | Article |
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| Institutional Unit: | Schools > Kent and Medway Medical School |
| Former Institutional Unit: |
There are no former institutional units.
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| Funders: | Dutch Research Council (https://ror.org/04jsz6e67) |
| Depositing User: | Athina Mylona |
| Date Deposited: | 13 May 2026 22:15 UTC |
| Last Modified: | 13 May 2026 22:15 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/115038 (The current URI for this page, for reference purposes) |
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