Driving change: the evolution of alternative genetic codes

Santos, Manuel and Moura, Gabriela and Massey, Steven E. and Tuite, Mick F. (2004) Driving change: the evolution of alternative genetic codes. Trends in Genetics, 20 (2). pp. 95-102. ISSN 0168-9525. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Pioneering studies in the 1960s that elucidated the genetic code suggested that all extant forms of life use the same genetic code. This early presumption has subsequently been challenged by the discovery of deviations of the universal genetic code in prokaryotes, eukaryotic nuclear genomes and mitochondrial genomes. These studies have revealed that the genetic code is still evolving despite strong negative forces working against the fixation of mutations that result in codon reassignment. Recent data from in vitro, in vivo and in silico comparative genomics studies are revealing significant, previously overlooked links between modified nucleosides in tRNAs, genetic code ambiguity, genome base composition, codon usage and codon reassignment.

Item Type: Article
Additional information: 0168-9525 (Print) Journal Article Research Support, Non-U.S. Gov't Review
Uncontrolled keywords: Animals *Codon Evolution, Molecular *Genetic Code Genome Humans Models, Genetic Proteins/*genetics RNA, Transfer/genetics *Variation (Genetics)
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Protein Science Group
Depositing User: Mick Tuite
Date Deposited: 01 Oct 2008 14:00
Last Modified: 10 Jun 2014 11:14
Resource URI: https://kar.kent.ac.uk/id/eprint/11313 (The current URI for this page, for reference purposes)
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