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Driving change: the evolution of alternative genetic codes

Santos, Manuel, Moura, Gabriela, Massey, Steven E., Tuite, Mick F. (2004) Driving change: the evolution of alternative genetic codes. Trends in Genetics, 20 (2). pp. 95-102. ISSN 0168-9525. (doi:10.1016/j.tig.2003.12.009) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:11313)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.tig.2003.12.009

Abstract

Pioneering studies in the 1960s that elucidated the genetic code suggested that all extant forms of life use the same genetic code. This early presumption has subsequently been challenged by the discovery of deviations of the universal genetic code in prokaryotes, eukaryotic nuclear genomes and mitochondrial genomes. These studies have revealed that the genetic code is still evolving despite strong negative forces working against the fixation of mutations that result in codon reassignment. Recent data from in vitro, in vivo and in silico comparative genomics studies are revealing significant, previously overlooked links between modified nucleosides in tRNAs, genetic code ambiguity, genome base composition, codon usage and codon reassignment.

Item Type: Article
DOI/Identification number: 10.1016/j.tig.2003.12.009
Additional information: 0168-9525 (Print) Journal Article Research Support, Non-U.S. Gov't Review
Uncontrolled keywords: Animals *Codon Evolution, Molecular *Genetic Code Genome Humans Models, Genetic Proteins/*genetics RNA, Transfer/genetics *Variation (Genetics)
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences > Protein Science Group
Depositing User: Michael Tuite
Date Deposited: 01 Oct 2008 14:00 UTC
Last Modified: 06 May 2020 03:03 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/11313 (The current URI for this page, for reference purposes)
Tuite, Mick F.: https://orcid.org/0000-0002-5214-540X
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