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Draize Rabbit Eye Test Compatibility with Eye Irritation Thresholds in Humans: A Quantitative Structure-Activity Relationship Analysis

Abraham, Michael H., Hassanisadi, Mostafa, Jalali-Heravi, Mehdi, Ghafourian, Taravat, Cain, William.S., Cometto-Mun˜iz, J.Enrique (2003) Draize Rabbit Eye Test Compatibility with Eye Irritation Thresholds in Humans: A Quantitative Structure-Activity Relationship Analysis. Toxicological Sciences, 76 (2). pp. 384-391. ISSN 1096-6080. (doi:10.1093/toxsci/kfg242) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:10753)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1093/toxsci/kfg242

Abstract

Draize rabbit eye test scores, as modified maximum average

liquid-saturated vapor pressure P°. These 68 adjusted scores, as

irritation thresholds (EIT), expressed as log (1/EIT), for 23 compounds

rabbits for pure bulk liquids is shown to be perfectly compatible

compounds was analyzed by the general solvation equation of

to a five-parameter equation with R2 0.936, SD 0.433, AD

divided into a training set of 45 compounds, the corresponding

a test set with AD –0.037 and AAD 0.345 log units. Thus, the

values to around 0.4 log units. It is suggested that the mechanism

transfer of the compound to a biophase that is quite polar, is a

quite hydrophobic. The biophase does not resemble water or

plasma, but resembles an organic solvent such as N-methylformamide.

Item Type: Article
DOI/Identification number: 10.1093/toxsci/kfg242
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 20 Oct 2008 13:28 UTC
Last Modified: 28 May 2019 13:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/10753 (The current URI for this page, for reference purposes)
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