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Paediatric anatomical models in radiotherapy applications

Apte, V, Ghose, A, Linares, C A, Adeleke, S, Papadopoulos, V, Rassy, E, Boussios, Stergios (2024) Paediatric anatomical models in radiotherapy applications. Clinical Oncology, 36 (9). pp. 562-575. ISSN 0936-6555. E-ISSN 1433-2981. (doi:10.1016/j.clon.2024.06.051) (KAR id:106734)

Abstract

Anatomical models have key applications in radiotherapy, notably to help understand the relationship between radiation dose and risk of developing side effects. This review analyses whether age-specific computational phantoms, developed from healthy subjects and paediatric cancer patient data, are adequate to model a paediatric population. The phantoms used in the study were International Commission on Radiological Protection (ICRP), 4D extended cardiac torso (XCAT) and Radiotherapy Paediatric Atlas (RT-PAL), which were also compared to literature data. Organ volume data for 19 organs was collected for all phantoms and literature. ICRP was treated as the reference for comparison, and percentage difference (P.D) for the other phantoms were calculated relative to ICRP. Overall comparisons were made for each age category (1, 5, 10, 15) and each organ. Statistical analysis was performed using Microsoft Excel (version 16.59). The smallest P.D to ICRP was for Literature (-17.4%), closely followed by XCAT (26.6%). The largest was for RT-PAL (88.1%). The rectum had the largest average P.D (1,049.2%) and the large bowel had the smallest (2.0%). The P.D was 122.6% at age 1 but this decreased to 43.5% by age 15. Linear regression analysis showed a correlation between organ volume and age to be the strongest for ICRP (R = 0.943) and weakest for XCAT (R = 0.676). The phantoms are similar enough to ICRP for potential use in modelling paediatric populations. ICRP and XCAT could be used to model a healthy population, whereas RT-PAL could be used for a population undergoing/after radiotherapy.

Item Type: Article
DOI/Identification number: 10.1016/j.clon.2024.06.051
Uncontrolled keywords: age-specific; organ volume; phantoms; paediatric cancer; radiotherapy
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 01 Aug 2024 14:04 UTC
Last Modified: 02 Aug 2024 12:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/106734 (The current URI for this page, for reference purposes)

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