Xue, Zheng-Kai, Dai, Xin-Ya, Ren, Jia-Yi, Liu, Tong, Zhang, Yu-Kun, Hu, Su-Tao, Wang, Peng, Wu, Xue, Zhang, Jing-Kun, Tse, Gary, and others. (2024) Prevalence, clinical characteristics, and long-term outcomes of new diabetes diagnosis in elderly patients undergoing percutaneous coronary intervention. Scientific Reports, 14 (1). Article Number 14814. E-ISSN 2045-2322. (doi:10.1038/s41598-024-65426-1) (KAR id:106538)
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Official URL: https://doi.org/10.1038/s41598-024-65426-1 |
Abstract
Previous studies have reported associations between newly diagnosed diabetes and poor outcomes after percutaneous coronary intervention (PCI), but there is limited data focusing on elderly patients (age ≥ 65). This study aimed to analyze the prevalence and clinical implications of newly diagnosed diabetes in elderly patients who underwent PCI. From 2004 to 2021, a total of 2456 elderly patients who underwent invasive PCI at Korea University Guro Hospital were prospectively enrolled and followed up for a median of five years. The primary endpoint was five-year major adverse cardiovascular events (MACE). Cox regression was used to evaluate whether newly diagnosed diabetes impacted on long-term clinical outcomes. Newly diagnosed diabetes was presented in approximately 8.1% to 10.9% of elderly patients who underwent PCI. Those who had a new diagnosis of diabetes had a higher risk of MACE than previously known diabetes (25.28% vs. 19.15%, p = 0.039). After adjusting for significant factors, newly diagnosed diabetes remained an independent predictor of MACE (HR [hazard ratio] 1.64, 95% confidence interval [CI] 1.24-2.17, p < 0.001), cardiac death (HR 2.15, 95% CI 1.29-3.59, p = 0.003) and repeat revascularization (HR 1.52, 95% CI 1.09-2.11, p = 0.013), but not for non-fatal myocardial infarction (HR 1.66, 95% CI 0.94-2.12, p = 0.081). Newly diagnosed diabetes was associated with an increased risk of 5-year MACE compared with non-diabetes and previously diagnosed diabetes in elderly patients underwent PCI. More attention should be given to those elderly newly diagnosed diabetes population.
Item Type: | Article |
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DOI/Identification number: | 10.1038/s41598-024-65426-1 |
Uncontrolled keywords: | Humans, Percutaneous Coronary Intervention - adverse effects, Treatment Outcome, Elderly, Newly diagnosed diabetes, Proportional Hazards Models, Risk Factors, Percutaneous coronary intervention, Female, Prevalence, Male, Aged, Republic of Korea - epidemiology, Aged, 80 and over, Prospective Studies, Coronary artery disease, Diabetes Mellitus - epidemiology |
Subjects: | R Medicine |
Divisions: | Divisions > Division of Natural Sciences > Kent and Medway Medical School |
SWORD Depositor: | JISC Publications Router |
Depositing User: | JISC Publications Router |
Date Deposited: | 12 Jul 2024 13:41 UTC |
Last Modified: | 05 Nov 2024 13:12 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/106538 (The current URI for this page, for reference purposes) |
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