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Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment.

Huang, Helen Ye Rim, Wireko, Andrew Awuah, Miteu, Goshen David, Khan, Adan, Roy, Sakshi, Ferreira, Tomas, Garg, Tulika, Aji, Narjiss, Haroon, Faaraea, Zakariya, Farida, and others. (2024) Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment. Medicine, 103 (13). Article Number e37567. ISSN 1536-5964. (doi:10.1097/md.0000000000037567) (KAR id:105565)


Juvenile idiopathic arthritis (JIA) is a chronic clinical condition characterized by arthritic features in children under the age of 16, with at least 6 weeks of active symptoms. The etiology of JIA remains unknown, and it is associated with prolonged synovial inflammation and structural joint damage influenced by environmental and genetic factors. This review aims to enhance the understanding of JIA by comprehensively analyzing relevant literature. The focus lies on current diagnostic and therapeutic approaches and investigations into the pathoaetiologies using diverse research modalities, including in vivo animal models and large-scale genome-wide studies. We aim to elucidate the multifactorial nature of JIA with a strong focus towards genetic predilection, while proposing potential strategies to improve therapeutic outcomes and enhance diagnostic risk stratification in light of recent advancements. This review underscores the need for further research due to the idiopathic nature of JIA, its heterogeneous phenotype, and the challenges associated with biomarkers and diagnostic criteria. Ultimately, this contribution seeks to advance the knowledge and promote effective management strategies in JIA.

Item Type: Article
DOI/Identification number: 10.1097/md.0000000000037567
Uncontrolled keywords: Animals, Humans, Phenotype, Child, Infant, Arthritis, Juvenile, Biomarkers
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 10 Apr 2024 13:42 UTC
Last Modified: 19 Apr 2024 10:28 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Khan, Adan.

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