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Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4.

Ghose, Aruni, McCann, Lucy, Makker, Shania, Mukherjee, Uma, Gullapalli, Sri Vidya Niharika, Erekkath, Jayaraj, Shih, Stephanie, Mahajan, Ishika, Sanchez, Elisabet, Uccello, Mario, and others. (2024) Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4. Therapeutic advances in medical oncology, 16 . ISSN 1758-8340. E-ISSN 1758-8359. (doi:10.1177/17588359241233225) (KAR id:105287)


Ovarian cancer (OC) is the most lethal gynaecologic malignancy, attributed to its insidious growth, non-specific symptoms and late presentation. Unfortunately, current screening modalities are inadequate at detecting OC and many lack the appropriate specificity and sensitivity that is desired from a screening test. Nearly 70% of cases are diagnosed at stage III or IV with poor 5-year overall survival. Therefore, the development of a sensitive and specific biomarker for early diagnosis and screening for OC is of utmost importance. Currently, diagnosis is guided by CA125, the patient's menopausal status and imaging features on ultrasound scan. However, emerging evidence suggests that a combination of CA125 and HE4 (another serum biomarker) and patient characteristics in a multivariate index assay may provide a higher specificity and sensitivity than either CA125 and HE4 alone in the early detection of OC. Other attempts at combining various serum biomarkers into one multivariate index assay such as OVA1, ROMA and Overa have all shown promise. However, significant barriers exist before these biomarkers can be implemented in clinical practice. This article aims to provide an up-to-date review of potential biomarkers for screening and early diagnosis of OC which may have the potential to transform its diagnostic landscape.

Item Type: Article
DOI/Identification number: 10.1177/17588359241233225
Uncontrolled keywords: Ovarian cancer, Diagnostic Biomarkers, Molecular Testing, Tumour Biomarkers, Circulating Tumour Biomarkers
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 13 Mar 2024 15:42 UTC
Last Modified: 14 Mar 2024 01:31 UTC
Resource URI: (The current URI for this page, for reference purposes)

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