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Mechanotransduction through protein stretching

Guo, Yanyu, Yan, Jie, Goult, Benjamin T (2024) Mechanotransduction through protein stretching. Current Opinion in Cell Biology, 87 . Article Number 102327. E-ISSN 1879-0410. (doi:10.1016/j.ceb.2024.102327) (KAR id:104823)

Abstract

Cells sense and respond to subtle changes in their physicality, and via a myriad of different mechanosensitive processes, convert these physical cues into chemical and biochemical signals. This process, called mechanotransduction, is possible due to a highly sophisticated machinery within cells. One mechanism by which this can occur is via the stretching of mechanosensitive proteins. Stretching proteins that contain force-dependent regions results in altered geometry and dimensions of the connections, as well as differential spatial organization of signals bound to the stretched protein. The purpose of this mini-review is to discuss some of the intense recent activity in this area of mechanobiology that strives to understand how protein stretching can influence signaling outputs and cellular responses.

Item Type: Article
DOI/Identification number: 10.1016/j.ceb.2024.102327
Uncontrolled keywords: Talin, mechanotransduction, mechanobiology, integrins, binary
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Funders: Cancer Research UK (https://ror.org/054225q67)
Depositing User: Ben Goult
Date Deposited: 31 Jan 2024 21:59 UTC
Last Modified: 02 Feb 2024 04:38 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/104823 (The current URI for this page, for reference purposes)

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