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Supercritical Fluids: A Promising Technique in Pharmaceutics

Trivedi, Vivek and Ajiboye, Adejumoke Lara (2023) Supercritical Fluids: A Promising Technique in Pharmaceutics. In: Nano- and Microfabrication Techniques in Drug Delivery. Springer Link, pp. 295-320. E-ISBN 978-3-031-26908-0. (doi:10.1007/978-3-031-26908-0_12) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:104574)

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The unique properties of supercritical carbon dioxide provide numerous opportunities for developing environmentally friendly pharmaceutical processes. The applications of supercritical carbon dioxide range from particle engineering to encapsulation to biopolymeric scaffold manufacturing. Moreover, the tunable nature of supercritical carbon dioxide can also impart interesting properties in the final product that may not be possible via any other conventional process. This chapter aims to provide an overview of the available processes and techniques according to the role of supercritical carbon dioxide and how can those be applied in pharmaceutical research and development and manufacturing. The application of supercritical carbon dioxide as solvent, antisolvent and solute/additive is discussed along with examples to highlight advancements in this field and how pharmaceutical manufacturing could benefit from moving to a greener and cleaner processing technique that is environmentally sustainable.

Item Type: Book section
DOI/Identification number: 10.1007/978-3-031-26908-0_12
Uncontrolled keywords: Supercritical carbon dioxide, Drug delivery systems, Rapid Expansion of Supercritical Solutions (RESS), Supercritical antisolvent (SAS), Gas antisolvent (GAS), Particles from gas-saturated solutions (PGSS), Green processing
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Vivek Trivedi
Date Deposited: 10 Jan 2024 15:21 UTC
Last Modified: 10 Jan 2024 22:41 UTC
Resource URI: (The current URI for this page, for reference purposes)

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