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Alternative Oxidase – Aid or obstacle to combat the rise of fungal pathogens?

Edrich, Elizabeth, Duvenage, Lucian, Gourlay, Campbell W. (2024) Alternative Oxidase – Aid or obstacle to combat the rise of fungal pathogens? Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1865 (2). Article Number 149031. ISSN 0005-2728. (doi:10.1016/j.bbabio.2024.149031) (KAR id:104571)


Fungal pathogens present a growing threat to both humans and global health security alike. Increasing evidence of antifungal resistance in fungal populations that infect both humans and plant species has increased reliance on combination therapies and shown the need for new antifungal therapeutic targets to be investigated. Here, we review the roles of mitochondria and fungal respiration in pathogenesis and discuss the role of the Alternative Oxidase enzyme (Aox) in both human fungal pathogens and phytopathogens. Increasing evidence exists for Aox within mechanisms that underpin fungal virulence. Aox also plays important roles in adaptability that may prove useful within dual targeted fungal-specific therapeutic approaches. As improved fungal specific mitochondrial and Aox inhibitors are under development we may see this as an emerging target for future approaches to tackling the growing challenge of fungal infection.

Item Type: Article
DOI/Identification number: 10.1016/j.bbabio.2024.149031
Uncontrolled keywords: Alternative OxidaseMitochondriaFungiPlantsPathogen
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Funders: University of Kent (
Depositing User: Campbell Gourlay
Date Deposited: 10 Jan 2024 14:52 UTC
Last Modified: 24 Jan 2024 14:10 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Edrich, Elizabeth.

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Gourlay, Campbell W..

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