Skip to main content

Quantitative structure-pharmacokinetic relationship modelling: apparent volume of distribution

Ghafourian, Taravat, Barzegar-Jalali, Mohammad, Hakimiha, Nasim, Cronin, Mark T.D. (2004) Quantitative structure-pharmacokinetic relationship modelling: apparent volume of distribution. Journal of Pharmacy and Pharmacology, 56 (3). pp. 339-350. ISSN 0022-3573. (doi:10.1211/0022357022890) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:10420)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1211/0022357022890

Abstract

The purpose of this study was to develop a quantitative structure–activity relationship (QSAR) for the

The relationship of many computed, and some experimental, structural descriptors with Vd, and the

stepwise regression analysis for all the 70 drugs in the dataset, as well as for acidic drugs and basic

set, and revealed that the models for Vd yielded lower prediction errors than those constructed for

separation of the compounds into acids and bases did not reduce the prediction error significantly.

Item Type: Article
DOI/Identification number: 10.1211/0022357022890
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 18 Sep 2008 15:22 UTC
Last Modified: 28 May 2019 13:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/10420 (The current URI for this page, for reference purposes)
  • Depositors only (login required):