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The effect of penetration enhancers on drug delivery through skin: a QSAR study

Ghafourian, Taravat, Zandasrar, Parinaz, Hamishekar, Hamed, Nokhodchi, Ali (2004) The effect of penetration enhancers on drug delivery through skin: a QSAR study. Journal of Controlled Release, 99 (1). pp. 113-125. ISSN 0168-3659. (doi:10.1016/j.jconrel.2004.06.010) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:10416)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1016/j.jconrel.2004.06.010

Abstract

Skin penetration enhancers are used to allow formulation of transdermal delivery systems for drugs that are otherwise

and for the choice of the enhancer to be used in the topical formulation of a special drug. In this study, the structural

technique. Activities of naturally occurring terpenes, pyrrolidinone and N-acetylprolinate derivatives on the skin penetration of

QSARs indicated that for 5-fluorouracil and diclofenac sodium, less hydrophobic enhancers were the most active. More

donor–acceptor interactions. This was in contrast to the skin permeation promotion of hydrocortisone, estradiol and benazepril

was evident. The possible mechanisms of penetration enhancement as suggested by the QSARs will be discussed.

Item Type: Article
DOI/Identification number: 10.1016/j.jconrel.2004.06.010
Uncontrolled keywords: skin absorption; QSAR; enhancer; transdermal penetration; transdermal permeation; permeation enhancer; penetration enhancer; hydrophobicity; lipophilicity
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 23 Sep 2008 17:18 UTC
Last Modified: 28 May 2019 13:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/10416 (The current URI for this page, for reference purposes)
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