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Solvent-induced transient self-assembly of peptide gels: gelator-solvent reactions and material properties correlation

Chevigny, Romain, Rahkola, Henna, Sitsanidis, Efstratios D., Korhonen, Elsa, Hiscock, Jennifer R., Pettersson, Mika, Nissinen, Maija (2023) Solvent-induced transient self-assembly of peptide gels: gelator-solvent reactions and material properties correlation. Chemistry of Materials, . ISSN 0897-4756. E-ISSN 1520-5002. (In press) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:104154)

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Abstract

Herein, we introduce a new methodology for designing transient organogels that offers tunability of the mechanical properties simply by matching the precursor’s protective groups to that of the solvent. We developed solvent-induced transient materials in which the solvent chemically participates in a set of reactions and actively supports the assembly event. The activation of a single precursor by an acid (accelerator) yields the formation of two distinct gelators and induces gelation. The interconversion cycle is supplied by the secondary solvent (originating from the hydrolysis of the primary solvent by the accelerator), which then progressively solubilizes the gel network. We show that this gelation method offers a direct correlation between the mechanical

and transient properties by modifying the chemical structure of the precursors and the presence of accelerator in the system. Such a method paves the way for designing self-abolishing and mechanically tunable materials for targeted purposes. The biocompatibility and versatility of amino acid-based gelators can offer a wide range of biomaterials for applications requiring a controllable and definite lifetime, such as drug delivery platforms exhibiting a burst release or self-abolishing cell culture substrates

Item Type: Article
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: UK Research and Innovation (https://ror.org/001aqnf71)
Depositing User: Jennifer Hiscock
Date Deposited: 01 Dec 2023 17:58 UTC
Last Modified: 04 Dec 2023 12:38 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/104154 (The current URI for this page, for reference purposes)

University of Kent Author Information

Hiscock, Jennifer R..

Creator's ORCID: https://orcid.org/0000-0002-1406-8802
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