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Patterns of chromosome evolution in ruminant

Arias-Sardá, Cristina, Quigley, Sarah, Farré, Marta (2023) Patterns of chromosome evolution in ruminant. Molecular Ecology, . ISSN 1365-294X. (doi:10.1111/mec.17197) (KAR id:103987)


Studying when and where gross genomic rearrangements occurred during evolution is key to understanding changes in genome structure with functional consequences that might eventually lead to speciation. Here we identified chromosome rearrangements in ruminants, a clade characterized by large chromosome differences. Using 26 genome assemblies, we reconstructed five ancestral karyotypes and classified the rearrangement events occurring in each lineage. With these reconstructions, we then identified evolutionary breakpoints regions (EBRs) and synteny fragments. Ruminant karyotype evolution is characterized by inversions, while interchromosomal rearrangements occurred preferentially in the oldest ancestor of ruminants. We found that EBRs are depleted of protein coding genes, including housekeeping genes. Similarly, EBRs are not enriched in high GC regions, suggesting that meiotic double strand breaks might not be their origin. Overall, our results characterize at fine detail the location of chromosome rearrangements in ruminant evolution and provide new insights into the formation of EBRs.

Item Type: Article
DOI/Identification number: 10.1111/mec.17197
Uncontrolled keywords: Molecular Evolution, Chromosome evolution, Genomics/Proteomics, Comparative genomics, Mammals
Subjects: Q Science
Q Science > QH Natural history > QH301 Biology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 12 Mar 2024 10:05 UTC
Last Modified: 13 Mar 2024 11:11 UTC
Resource URI: (The current URI for this page, for reference purposes)

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