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Association of Late Potentials With Fatal Arrhythmic Events in Patients With Brugada Syndrome — A Meta-analysis

Bazoukis, George, Letsas, Konstantinos P, Liu, Tong, Tse, Gary, Alsheikh-Ali, Alawi (2023) Association of Late Potentials With Fatal Arrhythmic Events in Patients With Brugada Syndrome — A Meta-analysis. Cardiology in Review, . ISSN 1538-4683. (doi:10.1097/crd.0000000000000511) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:103326)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1097/crd.0000000000000511

Abstract

Risk stratification of patients with Brugada syndrome (BrS) remains challenging. Signal-averaged electrocardiogram (SAECG) is a noninvasive tool that can be used to identify the electrophysiologic substrate potentially underlying fatal ventricular arrhythmias. The aim of this meta-analysis is to summarize the existing evidence about the role of late potentials (LP) as a predictor for arrhythmic events in patients with BrS. A systematic search in the MedLine database through to June 2022 without any limitations was performed. Ten studies were included in the quantitative synthesis (1431 patients with BrS, mean age 47.4 years, males 86%). Of these, 1220 patients underwent SAECG evaluation (53.2% had positive LP, and 20.6% had a fatal arrhythmic event). There was a nonsignificant association between positive LPs and fatal arrhythmic events [RR: 2.06 (0.98–4.36), P = 0.06, I2 = 82%]. By including only studies with patients without a history of fatal arrhythmia, the association between LP with arrhythmic events remained nonsignificant [RR: 1.29 (0.67–2.48), P = 0.44, I2 = 54%]. In conclusion, there is a possible association between LP and fatal arrhythmic events in patients with BrS, but the literature remains inconclusive. Large cohort studies using a multiparametric approach for risk stratification purposes are needed to improve the risk stratification of BrS and to optimize the selection of BrS patients that should be referred for implantable cardioverter-defibrillator.

Item Type: Article
DOI/Identification number: 10.1097/crd.0000000000000511
Uncontrolled keywords: Brugada syndrome, risk stratification, late potentials, signal-averaged electrocardiogram
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 31 Oct 2023 13:13 UTC
Last Modified: 01 Nov 2023 12:29 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/103326 (The current URI for this page, for reference purposes)

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