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Assessing the endometrium: an update on current and potential novel biomarkers of receptivity

Garratt, J., Rahmati, M. (2023) Assessing the endometrium: an update on current and potential novel biomarkers of receptivity. Journal of Reproductive Immunology, 160 . Article Number 104162. ISSN 0165-0378. E-ISSN 1872-7603. (doi:10.1016/j.jri.2023.104162) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:103186)

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https://doi.org/10.1016/j.jri.2023.104162

Abstract

A cyclical evolvement of the endometrium into a transient state of receptivity is crucial for acceptance of the semi-allogeneic foetus, conducive to pregnancy. Despite documentation of aberrances in this process within patients experiencing repeated embryo implantation failures and miscarriages, the endometrium is often overlooked in IVF clinics as the cause for failure. Focus instead is usually given to embryo-derived factors, such as aneuploidy. Nevertheless, failure of approximately 30% of euploid embryos to implant demonstrates that other factors such as the endometrium require clinical exploration. Here, we review both traditional and novel methods used to assess endometrial receptivity such as identifying the WOI, endometrial immune profiling and transcriptomics panel testing. Where reported, we will also discuss their clinical application, as well as novel potential biomarkers within the pre-clinical research stages which show promise in their ability to assess endometrial receptivity.

Item Type: Article
DOI/Identification number: 10.1016/j.jri.2023.104162
Uncontrolled keywords: Endometrial immune assessment, Repeated embryo implantation failure, Embryo implantation, Endometrial profiling, Endometrial biomarkers
Subjects: Q Science
Q Science > QH Natural history > QH301 Biology
Divisions: Divisions > Division of Natural Sciences > Biosciences
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 11 Oct 2023 13:46 UTC
Last Modified: 14 Feb 2024 16:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/103186 (The current URI for this page, for reference purposes)

University of Kent Author Information

Garratt, J..

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